Precision, safety and maximum efficiency
Syringe filling machines for processing RTU syringes in the nest
A syringe filling machine is an essential component in modern pharmaceutical manufacturing, enabling precise and aseptic filling of injectable drugs. It ensures consistent product quality, maximum process reliability and compliance with the highest regulatory standards. Our syringe filling machine portfolio covers a broad performance range – from compact systems for small clinical batches to fully automated high-performance machines capable of filling up to 60,000 syringes per hour. Designed for start-ups, CDMOs, biotech companies and global pharmaceutical manufacturers alike, our solutions provide the flexibility to support every stage of drug production, from clinical development to large-scale commercial manufacturing.
A key advantage of our aseptic syringe filling machines is their full compatibility with ready-to-use (RTU) packaging materials - like other RTU containers such as vials or cartridges. Whether standardised pre-sterilised syringes or special primary packaging: Our systems ensure gentle handling and consistently high product quality. RTU packaging materials reduce complex preparation steps and significantly minimise the risk of contamination.
For maximum flexibility, our pharmaceutical syringe filling machines can process RTU syringes in a nest. Nest processing enables safe handling of sensitive objects, reduces the risk of breakage and supports a highly efficient filling process with a small footprint. This is particularly beneficial for high-value liquid products such as biologics, vaccines or personalised therapies, where precision and loss-free processing are essential. Our systems maintain stable, controlled conditions throughout the filling and closing process to ensure reproducible and regulatory compliant results.
Each automatic syringe filling machine can be customised to meet specific production requirements. Modular designs, scalable performance ranges and various dosing systems enable optimum adaptation to different formulations – from low-viscosity solutions to high-viscosity liquids.
With proven design, advanced automation and a strong focus on aseptic safety, our pharmaceutical syringe filling equipment offer maximum process integrity, flexibility and long-term efficiency. This makes them the ideal choice for manufacturers looking for reliable quality and scalable performance in syringe processing.
Syringes filling machines for aseptic pharma production
Technical specifications
Performance
60,000
Syringes per hour
Processing range
0,5-50
ml per syringe
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Aseptic syringe filling machine
Frequently Asked Questions About Syringe Filling Machines
Explore the most important questions about syringe filling machines and aseptic pharmaceutical production. Learn how Bausch+Ströbel solutions support safe RTU syringe processing, precise dosing, and scalable manufacturing for modern injectable drug products.
A syringe filling machine is a pharmaceutical system designed to fill sterile drug products into pre-sterilized syringes with high accuracy and under aseptic conditions. These machines are used for the production of biologics, vaccines, and other injectable medicines where product quality and patient safety are critical.
Bausch+Ströbel syringe filling machines are specifically developed for the safe processing of ready-to-use (RTU) syringes in the nest. By using pre-sterilized packaging materials, manufacturers can simplify production processes and reduce contamination risks.
The machines combine precise dosing, automated stoppering, and integrated process controls to ensure reliable and reproducible filling results. Their modular design allows adaption to different products, fill volumes, and production capacities, from clinical batches to high-output commercial manufacturing.
As a result, pharmaceutical manufacturers benefit from high process reliability, regulatory compliance, and maximum product quality throughout the entire filling process.
An aseptic syringe filling machine fills sterile pharmaceutical products into syringes while maintaining product integrity and aseptic conditions throughout the process.
At Bausch+Ströbel, the process starts with the transfer of pre-sterilized RTU syringes into the aseptic production area. Technologies such as No-Touch Transfer (NTT) help minimize interventions and support Annex 1-compliant manufacturing.
The product is then filled using an application-specific dosing system such as rotary piston pumps, peristaltic pumps, or time-pressure dosing. After filling, syringes are automatically stoppered and transferred to the next production stage.
Integrated in-process controls continuously monitor filling accuracy and support stable production conditions. Additional options such as vacuum-assisted filling, gas flushing, and camera inspections further increase process reliability and product quality.
Ready-to-use (RTU) syringe processing offers significant advantages for modern pharmaceutical manufacturing. Since syringes are delivered pre-sterilized, washing, depyrogenation, and sterilization processes are no longer required.
This reduces operational complexity, lowers contamination risks, and shortens implementation times for new production projects. RTU processing also enables more flexible manufacturing, especially for small batches and high-value products.
Bausch+Ströbel syringe filling machines are designed for the safe handling of nested RTU syringes. Nest processing protects sensitive containers and supports reliable aseptic production.
Combined with advanced automation and Annex-1-oriented machine concepts, RTU solutions help pharmaceutical manufacturers improve efficiency, flexibility, and process safety.
Bausch+Ströbel syringe filling machines are suitable for a wide range of sterile pharmaceutical products. Typical applications include biologics, vaccines, monoclonal antibodies, recombinant proteins, and conventional injectable medicines.
The systems can also process advanced therapies and other high-value pharmaceutical products that require gentle handling and precise dosing.
Different dosing technologies allow reliable filling of both low-viscosity and highly viscous formulations. This ensures excellent filling performance regardless of product characteristics.
Thanks to their flexible design, Bausch+Ströbel machines support various syringe formats, fill volumes, and production requirements, making them suitable for both clinical and commercial manufacturing.
Filling accuracy is a key factor in pharmaceutical production. Bausch+Ströbel syringe filling machines are designed to achieve highly precise and reproducible dosing results across a broad range of applications.
Depending on the product and fill volume, manufacturers can choose from different dosing technologies, including rotary piston pumps, peristaltic pumps, and time-pressure systems. Each solution is selected to provide optimum performance for the specific application.
Integrated in-process controls continuously monitor filling performance and automatically compensate for deviations when necessary. Additional technologies such as vacuum-assisted filling further support consistent results.
The combination of precision engineering and advanced automation helps reduce product loss, improve batch consistency, and maintain compliance with GMP requirements.
Bausch+Ströbel offers syringe filling machines for both small-scale and large-scale pharmaceutical production. Depending on the machine configuration, outputs range from clinical batch production to high-performance commercial manufacturing.
For large-scale applications, systems can process up to 60,000 syringes per hour while maintaining high filling accuracy and aseptic safety.
Actual production output depends on factors such as syringe format, product properties, fill volume, dosing technology, and inspection requirements. Bausch+Ströbel focuses on achieving the ideal balance between throughput, quality, and process reliability.
Through intelligent automation and integrated process controls, manufacturers can achieve high productivity while meeting the stringent requirements of modern pharmaceutical production.
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