VarioSys module Bottles and vials vials

Machine module KSF 5105

Machine module KSF 5105 fills and closes bottles and vials in the VarioSys production system. The dosing station is designed to process liquid products using rotary piston pumps. However, it can also be equipped with alternative dosing technology such as peristaltic pumps or a time-pressure dosing system. Powder products can also be processed with our add-on powder dosing module. After the dosing cycle, the containers are closed fully automatically with up to two different types of closure. Insertable closures and plain crimp caps, as well as pre-assembled caps such as flip-off caps, flip top caps, flip tear up caps etc., are processed reliably and gently. In accordance with the overall machine concept, this module is designed to feed closures to the pick-up position with absolutely minimal particle emission.

Please find further information about our innovative and highly versatile VarioSys production system here:
www.variosys.com

Highlights

  • Mobile, space-saving production system in an isolator
  • Liquid or powder products
  • Up to two different types of closure
  • Pharmaceutical design
  • KSF 5105
  • KSF 5105
  • KSF 5105
  • KSF 5105
  • KSF 5105
  • VarioSys_DDM_KSF
Type of machineOutputProcessing area
KSF5105
  • up to 3,600 items/h
  • Container diameter: 14.25 - 52 mm
  • Container height: 35 - 130 mm
Technical data depend on machine equipment and packaging.
Easy and centralized operation
Compact design
Low-particle closure feed
  • Alternative dosing systems
  • In-Process Control (IPC)
  • Zero-loss start-up and running empty with minimal product loss
  • ECOfill
  • Gas flushing before and after filling
  • Bin and feed unit for optimized closure supply
  • Service portal vision system (cleanroom compatible)
  • A range of checking and alarm devices and counters
  • Software upgrades
  • Qualification (IQ/OQ)

ECOfill increases the number of vials filled per batch, maximizing your profit margin.

ECOfill ensures that effective use is made of your product batch. It doses your product within ultra-close dosing tolerances. All containers in a batch are filled to the optimal level so that, at most, only the last container may need to be rejected. The ECOfill dosing system consists of two dosing stations and works on a 2-stage dosing principle (rough dosing and fine dosing). It covers all phases of production – from start-up and production to running empty.

Benefits of the ECOfill dosing system:
  • "Benefit vials" – the product saved dose by dose
  • No need for manual intervention in the dosing area, e.g. during start-up or running empty
  • Ultra-close dosing tolerances
  • Availability from batch sizes as small as 1
  • Optimal product utilization
  • Resource-friendly technology

ADVANCEDfill ensures that optimal use is made of your product batch.
 ADVANCEDfill is a highly effective solution for processing your product. All containers in a batch are filled to the optimal level so that, at most, only the last container may need to be rejected. The ADVANCEDfill dosing system is equipped with a freely positionable needle holder. Product is dispensed directly into containers on the scales during start-up and running empty. This allows dose quantity to be monitored and setpoint deviations to be corrected in situ.

Benefits of the ADVANCEDfill dosing system:
  • No need for manual intervention in the dosing area, e.g. during start-up or running empty
  • Optimal product utilization
  • Availability from batch sizes as small as 1
  • Resource-friendly technology

Webinar
"Innovative Aseptic Processing of Antibody-Drug Conjugates"

Watch SKAN AG's Richard Denk and Bausch+Ströbel‘s Thomas Buehler as they dive into the latest developments in Innovative Aseptic Processing of Antibody-drug Conjugates.
With four antibody-drug conjugates (ADC) approved by the U.S. Food and Drug Administration (FDA), the development and manufacturing of targeted ADC therapies has become a booming field. Due to the intrinsic complexity of these drug entities, development and manufacturing of antibody-drug conjugates remains very challenging. Strict containment is required to guarantee the protection and safety of both operators and products.

Click here for more information

Upstream processing stages

DHT series

DHT

Sterilizing tunnel

Container typesCartridgesDisposable syringes (bulk ware)Bottles and vialsAmpulle

Max. output36,000 items/h

Downstream processing stages

Machine module KS 4105

KS 4105

VarioSys module

Container typesBottles and vials

Max. output3,600 items/h